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Rob Reiner and his wife Michele Singer have been found dead at their Los Angeles home.
On Sunday, a spokesperson for the Los Angeles Fire Department reported that a man and a woman had been discovered deceased at the Brentwood mansion owned by the couple.
A short time later, a law enforcement source confirmed to NBC News that Reiner, 78, and Singer, 68, were the victims, and had apparent stab wounds.
And in a statement issued to Variety, a representative for the Reiner family announced that the couple had died.
"It is with profound sorrow that we announce the tragic passing of Michele and Rob Reiner," they commented. "We are heartbroken by this sudden loss, and we ask for privacy during this unbelievably difficult time."
No further details were given.
Detectives from the Robbery Homicide Division (RHD) at the Los Angeles Police Department are investigating.
At a news conference, LAPD Deputy Chief Alan Hamilton emphasised that the process was still in a very early phase.
"We are not looking for anyone as a suspect or in any other manner at this time," he said. "We're going to try to speak to every family member that we can to get to the facts of this investigation."
Reiner, the son of actor Carl Reiner, rose to fame as the character of Mike 'Meathead' Stivic on the '70s sitcom, All in the Family. His other acting credits include 1993's Sleepless in Seattle, 1998's Primary Colors, and 2013's The Wolf of Wall Street.
But Reiner was perhaps best known for his filmmaking, having made his directorial debut with the 1984 mockumentary This Is Spinal Tap.
The Hollywood icon also helmed 1985's The Sure Thing, 1986's Stand by Me, 1987's The Princess Bride, 1989's When Harry Met Sally...,1990's Misery, and 1992's A Few Good Men.
Reiner and photographer Singer wed in 1989 and shared three children, sons Jake and Nick, and daughter Romy.
The New York native was also married to Penny Marshall from 1971 until 1981.
Reiner adopted the actress/director's daughter, Tracy Reiner, during the relationship.